13th International workshop on Clinical Pharmacology of HIV Therapy, 16-18 April 2012, Barcelona

1 June 2012. Related: Conference reports, PK and drug interactions, Conference index, PK Workshop 13th 2012.

This important annual workshop always includes studies that are not presented at other meetings and it is appreciated that the organisers have made both the abstract book and many of the presentations available to download in PDF format.

http://www.virology-education.com/

http://regist2.virology-education.com/abstractbook/2012_3.pdf

Reports on drug interactions are selected, and in some cases summarised, from a full report produced by the pharmacology group at Liverpool University (www.druginteractions.org).

The full Liverpool report is available online and in PDF format.

http://www.hiv-druginteractions.org/data/NewsItem/94_13%20PKW%20Barcelona.pdf

Studies in this HTB include:

• Studies on pipeline ARVs
• Washout pharmacokinetics of transplacental raltegravir in neonates
• Interactions between malaria drugs and etravirine or darunavir/r
• No interaction between antimalarial amodiaquine and nevirapine
• Pharmacokinetics of atazanavir/ritonavir plus raltegravir
• Atazanavir/ritonavir and voriconazole not to be coadministered
• Milk thistle (silymarin) and darunavir/ritonavir
• Echinacea and etravirine
• Warfarin and ARVs: impact of African American race and ritonavir

Abbreviations used in these reports include:

• Cmax = Maximum concentration
• Cmin = minimum concentration
• AUC = Area Under the Curve
• GMR = Geometric Mean Ratio
• IC90/50 = Inhibitory Concentration needed to reduce viral production by 90/50% in vitro.