Drug circulation in the bloodstream

Once they have reached the bloodstream, some drugs bind tightly to proteins in the blood such as albumin. In this form, the drugs are usually inactive and are quickly removed from the body. If a drug is highly protein-bound in this way, the dose is carefully chosen so that a large enough proportion of each dose remains unbound and therefore active in the body.

Some drugs are far more protein-bound than others. If you take two highly protein-bound drugs for example Drug X and Drug Y, Drug X may bind to most of the available protein in the blood, leaving little protein left to bind to Drug Y. That can mean that an unusually high proportion of each dose of Drug Y is left unbound and active, perhaps the equivalent of taking an overdose of Drug Y.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.