Drug interactions

Delavirdine (Rescriptor) is an inhibitor of the cytochrome P450 CYP3A4 system, a metabolic pathway in the liver, which eliminates drugs from the body. Combining delavirdine with protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept) or saquinavir (Invirase) may result in elevated protease inhibitor concentrations in the blood.1

Patients taking delavirdine should not take the following drugs, due to dangerous changes in drug levels:

  • Astemizole.
  • Alprazolam (Xanax).
  • Amiodarone (Cordarone X).
  • Carbamazepine (Tegretol / Carbagen / Tegretol Retard / Teril Retard / Timonil Retard).
  • Cisapride.
  • Ergotamine tartrate (Cafergot / Migril).
  • Hypericin (St John’s wort).
  • Lovastatin.
  • Midazolam (Hypnovel).
  • Phenobarbital.
  • Phenytoin (Epanutin).
  • Pimozide (Orap).
  • Quinidine (Kinidin Dureles).
  • Rifabutin (Mycobutin).2
  • Rifampicin (Rifadin / Rimactane).
  • Simvastatin (Zocor).
  • Terfenadine.
  • Triazolam.

References

  1. Fletcher CV et al. Competing drug-drug interactions among multidrug antiretroviral regimens used in the treatment of HIV-infected subjects: ACTG 884. AIDS 14: 2495-2501, 2000
  2. Borin MT et al. Pharmacokinetic study of the interaction between rifabutin and delavirdine mesylate in HIV-infected patients. Antivir Res 35: 53-63, 1997
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.