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Mechanism of HIV spread has potential for future drug therapy

A new understanding of the initial interactions of human immunodeficiency virus type 1 (HIV-1) and dendritic cells is described by Boston University School of Medicine (BUSM) researchers in a study currently featured in the Proceedings of the National Academy of Sciences (PNAS).

24 April 2012
Google Alerts HIV
HIV 'superinfection' boosts immune response: Findings may provide insight into HIV-vaccine development

Women who have been infected by two different strains of HIV from two different sexual partners – a condition known as HIV superinfection – have more potent antibody responses that block the replication of the virus compared to women who’ve only been infected once.

30 March 2012
Science Daily
Deeper view of HIV reveals impact of early mutations

Mutations in HIV that develop during the first few weeks of infection may play a critical role in undermining a successful early immune response, a finding that reveals the importance of vaccines targeting regions of the virus that are less likely to mutate.

09 March 2012
Science Daily (press release)
Psoriasis Linked to Protection from HIV-1

Many psoriasis patients have the same gene variants as people who are not significantly affected by an HIV-1 infection.

06 March 2012
Scientific American
Are HIV Non-Progressors Really Very Slow Progressors?

HIV positive people traditionally classified as long-term non-progressors or viral controllers may in fact progress slowly over time, according to research reported in the February 20, 2012, edition of the open-access journal PLoS ONE. These findings suggest that so-called non-progressors may in fact benefit from antiretroviral therapy and could provide clues to aid in development of immune-based therapies.

27 February 2012
Immune cells use 'starvation tactics' on HIV

Scientists have shown how some cells in the body can repel attacks from HIV by starving the virus of the building blocks of life. Viruses cannot replicate on their own; they must hijack other other cells and turn them into virus production factories.

12 February 2012
BBC News
Virus Related to HIV Found in One Quarter of Ape Hunters in Gabon

Nearly one quarter of humans bitten or scratched while hunting nonhuman primates in Gabon had evidence of simian foamy retrovirus (SFV), a virus closely related to HIV. The finding underlines the continuing risk of cross-species transmission of retroviruses.

18 January 2012
International AIDS Society
Pathogenic Landscape of HIV

In perhaps the most comprehensive survey of the inner workings of HIV, an international team of scientists led by researchers at the University of California, San Francisco has mapped every apparent physical interaction the virus makes with components of the human cells it infects—work that may reveal new ways to design future HIV/AIDS drugs.

21 December 2011
UCSF Today
Immediate ART during Early HIV Infection May Delay Disease Progression

People who started combination antiretroviral therapy (ART) within 6 months of HIV infection were less likely to experience large CD4 cell decreases or AIDS-related illnesses during follow-up, although viral load set point could not be evaluated, researchers reported.

19 December 2011
Semen Protein Boosts HIV Transmission

Researchers identify a protein in semen that enhances the transmission of HIV in culture, but whether it increases infectivity in humans is not yet known.

15 December 2011
The Scientist

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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.