Studies that led to the approval of etravirine showed that when combined with darunavir/ritonavir plus at least two nucleoside analogues selected by resistance testing, etravirine was significantly more effective than placebo in suppressing viral load in treatment-experienced people with at least one NNRTI resistance mutation and three or more primary protease inhibitor mutations.1 A subsequent study showed that etravirine was more effective in treatment-experienced people with fewer than three NNRTI mutations.2

Despite its impressive activity against NNRTI-resistant HIV, those findings showed that the more NNRTI resistance mutations a person has, the lower the viral load reduction. Individuals with no NNRTI resistance mutations at baseline had a median viral load reduction of nearly 3 logs after 34 weeks of etravirine treatment combined with an optimised background regimen. Those with three or more NNRTI mutations had a viral load reduction of less than a log.


  1. Katlama C et al. Efficacy and safety of etravirine in treatment-experienced, HIV-1 patients: pooled 48 week analysis of two randomized, controlled trials. AIDS 23(17): 2289-300, 2009
  2. TMC125-C223 Writing Group Efficacy and safety of etravirine (TMC125) in patients with highly resistant HIV-1: primary 24-week analysis. AIDS 21(6): F1-F10, 2007
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.