Fish oils and other supplements

A fish oil preparation that is rich in omega-3 triglycerides is able to reduce elevated triglycerides but may aggravate cholesterol levels. It is considered a relatively weak treatment and a large dosage would be needed to reduce the very high triglycerides associated with protease inhibitor therapy.

One trial has shown that, in patients taking antiretroviral therapy, taking 2g of a fish oil preparation called Maxepa three times daily for 8 weeks reduced triglyceride levels by an average of 25%, with no significant adverse events. Patients with the highest baseline triglyceride levels (> 10 g/L) had even larger reductions (median 44% reduction at 8 weeks). Despite the high pill burden, this treatment may be attractive due to the lack of drug interactions and its efficacy. 1

A small observational study of acetyl-L-carnitine, primarily being investigated as a treatment for peripheral neuropathy (nerve damage) associated with antiretroviral drugs, found little or no effect on triglycerides or body fat. 2

References

  1. De Truchis P et al. Reduction in triglyceride level with N-3 polyunsaturated fatty acids in HIV-infected patients taking potent antiretroviral therapy: a randomized prospective study. J Acquir Immune Defic Syndr 44:278-285, 2007
  2. Mauss S et al. L-carnitine in the treatment of HIV-associated lipodystrophy syndrome. HIV Medicine 2(1): 59-60, 2001
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.