Genes, genetics, and inheritance

The four processes that a drug goes through after being ingested are absorption, distribution, metabolism, and elimination. Genetic variation can affect each of these processes. For example, how much of a drug is absorbed, does it get to where it needs to go, does it work when it gets there, how long does it stay, and at what rate does it leave the body?

Of the four areas, pharmacogenetics has looked most closely at genetic differences in drug metabolism. Despite this concentration, only a handful of genetic variations have been found to have a predictive effect on outcomes.

Most currently licensed HIV drugs target proteins using the virus’s genetic material. The introduction of the CCR5 inhibitor maraviroc (Celsentri) changes this picture. This drug class targets human proteins, so genetic variation could possibly affect response to treatment.  

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.