Mitochondrial toxicity

Mitochondria are small rod-like structures, or organelles, located within cells. They serve as ‘power plants’ that produce the energy cells need to function, by processing fats and sugars from food and combining them with oxygen to create energy-storage molecules called adenosine triphosphate (ATP). This process is known as oxidative phosphorylation or cellular respiration. When needed, ATP is broken down to release this stored energy.

Mitochondria have their own supply of DNA (mtDNA) that is distinct from the normal DNA in the cell’s nucleus. As the mitochondria copy their DNA, errors are often made. As these dysfunctional mutations accumulate, the mitochondria become less able to generate energy efficiently.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.