Treatment interruptions

Treatment interruptions features

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  Barriers to care: immigration removal centres and HIV

  Evidence has shown that a series of failings in immigration removal centres (IRCs) has compromised the continuity of care for people with HIV. Guest writer Daniel Lombard investigates. ...

  From:  HIV treatment update

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  The return of treatment interruptions?

  By Edwin J Bernard. Reporting by Gus Cairns. ...

  From:  HIV treatment update

Treatment interruptions in your own words

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  Finally undetectable!

  After almost 15 years of HIV, and six years of viral load testing, I heard on Thursday, June 21st 2001 that my viral load had...

  From: In your own words

Treatment interruptions news from aidsmap

• Following an HIV treatment interruption, most children recover immunologically

  Just over one in ten (12%) children and adolescents living with HIV in Europe and Thailand take a break from antiretroviral treatment, usually as a result of their own decision, findings from the European Pregnancy and Paediatric HIV Cohort ...

  07 June 2019 | Carole Leach-Lemens

• Analytical treatment interruptions: minimising the risks and maximising their scientific value

  Recommendations for the safe and appropriate use of ‘analytical treatment interruptions’ have been developed by a group of HIV experts, including clinicians, patient advocates, bioethicists, social scientists and representatives from regulatory authorities, and recently published in The Lancet HIV. ...

  15 May 2019 | Alain Volny-Anne

• HIV-positive participant in vaccine study passes virus to sexual partner during treatment interruption

  An HIV-positive man transmitted HIV to his sexual partner after interrupting antiretroviral therapy as part of a research study into a therapeutic vaccine, French scientists reported in the Journal of Infectious Diseases last week. The case report underlines the ...

  01 March 2019 | Roger Pebody

• Atripla or efavirenz plus Truvada failed one in 16 people in first year

  Although analyses of the failure rate of ART have been conducted before, a new analysis is the first to compute these rates for a single-drug regimen – namely efavirenz, tenofovir and emtricitabine, the one used most frequently in ...

  21 January 2019 | Gus Cairns

• Viral load in semen rapidly rebounds to infectious levels during HIV treatment breaks

  Viral load rebounds rapidly in semen to potentially infectious levels following interruption of combination antiretroviral therapy (cART), according to French research published in AIDS.Increases in viral load in both blood and semen were observed within two weeks of treatment interruption. Four ...

  14 November 2018 | Michael Carter

• One in nine people may be able to control their viral load after stopping treatment, US study finds

  A US collaboration that pooled data from 14 scientific studies containing between them more than 600 HIV-positive people has found that 67 of them were able to maintain or re-establish a viral load below 400 copies/ml for at least ...

  16 August 2018 | Gus Cairns

• VRC01 antibody can delay but not prevent viral rebound after interruption of early treatment

  A broadly neutralising antibody modestly delayed the resurgence of viral replication following interruption of antiretroviral therapy (ART) started during very early infection, but all study participants ultimately experienced viral rebound, according to results presented last week at the 9th ...

  02 August 2017 | Liz Highleyman

• Researchers report case of bone marrow transplant patient off ART for 288 days without HIV rebound

  An HIV-positive bone marrow transplant recipient at the Mayo Clinic experienced prolonged viral remission lasting nearly 10 months – longer than the so-called Boston patients – after interrupting antiretroviral therapy (ART), according to a report at the Conference on ...

  06 March 2017 | Liz Highleyman

• VRC01 antibody delays but does not prevent HIV rebound after antiretroviral treatment interruption

  VRC01, a broadly neutralising antibody targeting HIV's CD4 binding site, was able to modestly delay the return of viral replication following interruption of antiretroviral therapy (ART), according to a study presented at the recent Conference on Retroviruses and Opportunistic Infections ...

  08 April 2016 | Liz Highleyman

• People taking a large number of non-HIV-related medications more likely to stop or change HIV drugs

  HIV-positive patients who are taking a large number of medications for the treatment of non-HIV-related conditions are at increased risk of stopping or changing their antiretroviral therapy (ART), according to Canadian research published in AIDS Patient Care and STDs. ...

  27 January 2016 | Michael Carter

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Treatment interruptions news selected from other sources

• Community Recommendations for Clinical Research Involving Antiretroviral Treatment Interruptions in Adults

  Scientists working to develop a cure for HIV infection sometimes need to conduct clinical trials in which participants are asked to temporarily interrupt ART, which contradicts the recommendations and guidelines for people with HIV under medical care.

  15 November 2018 | TAG

• Antiretroviral shortage reaches 100% in Venezuela

  Alberto Nieves, executive director of Acción Ciudadana Contra el SIDA (ACCSI) says: "By March 2018, the shortage of antiretroviral drugs reached 100% in Venezuela, which It is affecting more than 80 thousand people with HIV." Four of the 27 licensed antiretrovirals were still in stock but not ones necessary to construct viable combination therapy.

  17 April 2018 | Corresponsales Clave

• Is It Ethical to Take People Off HIV Meds for Cure Research?

  Cure studies typically require a temporary break in HIV treatment, often with little promise of a personal benefit to the participant.

  13 September 2017 | Poz

• Fast Rebound After Treatment Interruption in 9 of 10 With Low HIV DNA Reservoir

  Nine of 10 people with a cell-associated HIV DNA level below 100 copies/106 cells had an HIV RNA rebound within 12 weeks after antiretroviral therapy interruption. The 10th person maintained HIV RNA control without drugs for more than 48 weeks, according to a study published in AIDS.

  13 June 2016 | The Body PRO

• Markers of Immune Exhaustion Predict Post-Treatment Control in HIV Patients

  Biomarkers of immune exhaustion were associated with how long a patient was able to control HIV after treatment was interrupted, according to a study presented at CROI 2015.

  05 March 2015 | The Body

• The Search for a Permanent Alternative to HIV Drugs

  Researchers Carefully Tailor a Study to Find Patients to Test Going Off Antiretroviral Medication

  16 February 2015 | Wall Street Journal

• Russia may face shortage of anti-AIDS drugs in 2015

  Russia may face a shortage of anti-AIDS drugs in 2015 due to the current complex situation in the national economy and devaluation of the rouble, according to recent statements of Vadim Pokrovsky, head of the Russian Federal Research and Methodological Center for Prevention and Control of AIDS.

  29 January 2015 | EATG

• ARV supply issues cause treatment interruptions in a UK clinic

  We have been told of ARV stock-outs that resulted in patients having to interrupt HIV medication due to problems in drug supply. It is difficult to understand why a UK clinic would allow problems to develop to the point that this happened not just once, but several times.

  01 December 2014 | HIV i-Base

• Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

  Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure.

  15 March 2013 | PLoS Pathogens

• Malawi: Malawi's Never-Ending Drug Shortage Problem

  Malawi is again experiencing a crisis in the delivery of essential medicines, with understaffed clinics and erratic drug supplies preventing many dangerously ill patients from accessing treatment.

  20 February 2013 | AllAfrica

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