Hepatitis C is considered to be cured if the virus cannot be detected 12 weeks after completing treatment. This is called a sustained virological response (SVR).

Recommended direct-acting antiviral (DAA) regimens that combine drugs from different classes have shown overall cure rates of 95 to 100% in clinical studies.

SVR rates are somewhat lower for treatment-experienced people and those with advanced liver disease. But some of the newest DAA combinations also have high cure rates for people with cirrhosis or prior unsuccessful treatment. Most people can be successfully treated, although some may need longer treatment or a regimen that includes more DAAs or ribavirin.

If you do not respond to treatment the first time, a second attempt may be successful. This is especially likely if you were previously treated with interferon and ribavirin and are now able to try DAAs.

Hepatitis C treatment that leads to a cure reduces the likelihood of developing cirrhosis and liver cancer. People who already have advanced fibrosis or cirrhosis may see some improvement or reversal of existing liver damage.