Clinical trials

Triple PI salvage therapy

Keith Alcorn, Keith Alcorn
Published: 05 March 2001

Salvage therapy with three protease inhibitors alongside nucleoside analogues or the NNRTI efavirenz is being explored by clinicians at the Royal Free Hospital in London.

They reported on four patients with high level cross-resistance to at least two classes of drugs who had responded well to combinations containing three protease inhibitors. All four patients had been previously diagnosed with at least one AIDS-defining illness, and had received at least three regimens.

In all cases regimens were reported to be well tolerated and were taken twice daily with food (poster 20).

Reference

Dragovic B et al. Triple protease inhibitor combinations in patients with multi-drug resistant HIV infection..Sixth Annual Conference of the British HIV Association (BHIVA), abstract P20, 2000.

Patient, resistance profile

  

Baseline

Week 4

Follow-up to date

PIs

1 - multi-nucleoside resistant (Q151M), NNRTI and NFV resistant

VL

CD4

418,000

45

1906

68

400 @10m

367

RTV (100mg)

IND

SQV hg

Abacavir

Hydroxyurea

2 - L90M mutation, AZT/3TC,

poss d4T

VL

CD4

210

212

895

256

116 @w16

312

RTV

IND

APV

Delavirdine

3TC

d4T

hydoxyurea

3 - resistant to all NRTIs and NNRTIs except d4T;

5 month drug holiday

VL

CD4

500,000

29

N/a

23,167

@w12

139

RTV

SQVsg

APV

4 - no resistance data available

1 year drug holiday

VL

CD4

500,000

11

4,847

103

174,530

184

RTV

SQVsg

APV

Reference

Dragovic B et al. Triple protease inhibitor combinations in patients with multi-drug resistant HIV infection..Sixth Annual Conference of the British HIV Association (BHIVA), abstract P20, 2000.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
close

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.