A team led by Duke Human Vaccine Institute researchers, publishing online Dec. 11 in the journal Immunity, reported that they have filled in a portion of the roadmap toward effective neutralization of HIV, identifying the steps that a critical HIV antibody takes to develop and maintain its ability to neutralize the virus.
- Published
- 12 December 2018
- From
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Eurekalert Inf Dis
HIV induces antibody responses in infected individuals, but only a few of these individuals manage to produce antibodies that are capable of viral neutralization—and even fewer produce antibodies that can neutralize different strains of HIV.
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- 01 December 2018
- From
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Nature
A new candidate HIV vaccine from Scripps Research surmounts technical hurdles that stymied previous vaccine efforts, and stimulates a powerful anti-HIV antibody response in animal tests. The new vaccine strategy, described in a paper on November 23 in Science Advances, is based on the HIV envelope protein, Env. This complex, shape-shifting molecule has been notoriously difficult to produce in vaccines in a way that induces useful immunity to HIV. However, the Scripps Research scientists found a simple, elegant method for stabilizing Env proteins in the desired shape even for diverse strains of HIV. Mounted on virus-like particles to mimic a whole virus, the stabilized Env proteins elicited robust anti-HIV antibody responses in mice and rabbits. Candidate vaccines based on this strategy are now being tested in monkeys.
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- 27 November 2018
- From
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Scripps Research Institute
Money is just the obvious obstacle. A few diseases, like H.I.V., so far have outwitted both the immune system and scientists.
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- 22 November 2018
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New York Times
The HIV Research for Prevention conference (HIVR4P 2018) in Madrid last week was dominated by studies of one type of molecule – broadly neutralising antibodies
- Published
- 29 October 2018
- By
- Gus Cairns
A ‘functional cure’ of HIV has been achieved in one monkey given gene therapy that induced it to make two broadly neutralising antibodies against the
- Published
- 26 October 2018
- By
- Gus Cairns
HIV prevention research funding continued to decline in 2017 for the fifth consecutive year, driven largely by a five-year low in US public sector funding, according to a report released today at the HIV Research for Prevention (HIVR4P 2018) conference in Madrid, Spain.
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- 26 October 2018
- From
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HIV Prevention R&D Working Group
Johnson & Johnson has already advanced a “mosaic” HIV vaccine candidate into efficacy testing in five southern African countries, but this week the company unveiled initial results from an early-stage study comparing tetravalent and trivalent candidates in its program.
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- 24 October 2018
- From
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Fierce Pharma
The Global HIV Vaccine Enterprise, hosted by the International AIDS Society (IAS), has launched a five-year strategy to accelerate the development of an effective vaccine to prevent HIV infection. The new Global HIV Vaccine Enterprise Strategic Plan (2018-2023) was unveiled today at the opening of HIV Research for Prevention (HIVR4P 2018), the world’s only scientific conference dedicated exclusively to biomedical HIV prevention, in Madrid, Spain.
- Published
- 23 October 2018
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International AIDS Society
Duke researchers have recently discovered why some people can produce antibodies capable of fighting HIV, and the answer might lie in one special protein.
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- 18 October 2018
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Duke Chronicle
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