News from IDWeek 2019

Do integrase inhibitors increase the risk of diabetes?

People who started antiretroviral therapy with a regimen that included an integrase inhibitor were more likely to develop diabetes mellitus, although this increased risk differed between specific drugs, researchers reported at the IDWeek 2019 conference in Washington, DC.


Hepatitis C vaccine fails to prevent chronic infection

An experimental two-part vaccine was not able to prevent chronic hepatitis C virus infection in a mid-stage study, according to a presentation at the conference.


Ibalizumab monoclonal antibody is effective in real-world use

Ibalizumab (Trogarzo), a long-acting monoclonal antibody that prevents HIV from entering cells, suppressed HIV for 48 weeks in people with highly resistant virus who received the drug in an expanded access programme, according to a presentation at the conference.


Other aidsmap news

US FDA approves TAF-based PrEP for many people at risk for HIV

The US Food and Drug Administration (FDA) last week approved tenofovir alafenamide/emtricitabine (brand name Descovy), a combination pill containing an updated version of tenofovir, as a second pre-exposure prophylaxis (PrEP) option for many people. However, the indication does not include those at risk of acquiring HIV through vaginal sex.


No-deal Brexit threatens the health of UK citizens living with HIV in other European countries

There is little clarity about how UK citizens living in Spain and elsewhere in the European Union will continue to get HIV treatment in the event of a no-deal Brexit, posing risks both for individuals living with HIV and the public health, according to an article in the medical journal AIDS.


Exercise helps alleviate depression and anxiety for people living with HIV

Exercise reduces symptoms of depression and anxiety in people living with HIV, according to the results of a meta-analysis published in the Journal of Psychosomatic Research. The research additionally showed that aerobic exercise, training at least three times a week and exercising under professional supervision had the greatest benefits.


Nursing homes used by people living with HIV have poorer quality ratings

The proportion of nursing home residents living with HIV in the United States has increased markedly in recent years, but the facilities they are admitted to tend to be of poorer quality, researchers from Brown University report in two articles in the Journal of the American Geriatrics Society. One third of residents have some form of dementia or cognitive impairment.


First data on PrEP uptake in trans men

In a US national sample of transgender men and transmasculine individuals, a quarter had had sex which would make them eligible for PrEP. However, only a third of those eligible had had any PrEP information from their doctor, and only 11% had actually received a PrEP prescription.


Consent, power and age difference between young black gay couples may have more effect on HIV transmission than individual characteristics, US study finds

A quite large survey of young black gay and bisexual men in two Texan cities, Houston and Dallas, has found that power dynamics between gay couples may be the most important influence on the onward spread of HIV through the black gay community, rather than factors that disadvantage individuals such as youth, poverty or low education.


Point-of-care viral load testing results in more switches from failing treatment

Point-of-care viral load testing resulted in higher rates of switching and shorter periods on failing treatment than laboratory-based viral load testing in rural Malawi and has the potential to be "game-changing" for achievement of viral suppression goals, Médecins sans Frontières researchers report in the Journal of the International AIDS Society.


No evidence of risk compensation in female sex workers starting PrEP

Researchers found no evidence that female sex workers in Benin engaged in higher-risk behaviours after starting pre-exposure prophylaxis (PrEP). A novel methodology was used in order to measure this: the presence of biomarkers indicating exposure to semen in vaginal samples.


Editors' picks from other sources

South Africa delays rollout of new blockbuster HIV drug dolutegravir

from Bhekisisa

Stocks of the new treatment are already on the shelves of some clinics – but lingering concerns over a possible low risk of birth defects associated with this new antiretroviral have stalled the country’s switch to better medication for a second time.

HIV diagnosis for 15 men waiting for drug on NHS

from BBC News

At least 15 people in England have tested HIV positive while waiting to get a place on a trial for a pill which prevents HIV. England is the only place in the UK where places on a trial to access the drug through the NHS are restricted.

Shuping Wang, who helped expose China’s rural AIDS crisis, dies at 59

from The New York Times

Shuping Wang defied Chinese officials who tried to hide an AIDS epidemic in rural China. She helped expose the spread of HIV through shoddy facilities that bought blood from poor farmers.

Gilead duped me into being their mouthpiece. Here’s how

from My Fabulous Disease

This is the story of the insidious influence of big pharma on our HIV/AIDS leadership and policy making, and how an experienced activist like me was tricked into delivering messages for the HIV pharma giant Gilead Sciences.