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HATIP #82, 13th March 2007

Published: 13 March 2007

News headlines from the Fourteenth Conference on Retroviruses and Opportunistic Infections (CROI), Los Angeles

Extensive coverage of the major scientific meeting of 2007 from aidsmap.com

To view all news reports published, visit: http://www.aidsmap.com/cms1174967.asp

CROI: Is there a ceiling to CD4 recovery on virologically effective therapy?
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CROI: Is tenofovir causing kidney problems?
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CROI: Treatment changes and breaks occur at high rate in Ugandan HIV patients
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CROI: Remission of Kaposi's sarcoma seen in rural Uganda when HIV treatment given
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CROI: High dietary fat and cholesterol contribute to serum lipid levels in people with HIV
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CROI: High rate of virologic failure on once-daily combination of 3TC, tenofovir and nevirapine
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CROI: Sexually transmitted infections significantly increase risk of drug-resistant HIV transmission
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CROI: Use of both cotrimoxazole and insecticide-treated bednets dramatically lowers the risk of malaria in HIV-positive children
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CROI: Therapeutic concentrations of efavirenz, Kaletra, could be difficult to achieve in some children, with or without rifampicin
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CROI: Large Zambian study finds early abrupt weaning of HIV-exposed infants does not improve HIV-free survival
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CROI: Experimental 'salvage' integrase inhibitor, elvitegravir (GS-9137) appears potent at higher doses
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CROI: Four African studies suggest health risks associated with abrupt and early weaning of HIV-exposed infants
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CROI: Aciclovir therapy for women with HIV and herpes produces modest reductions in genital viral load
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CROI: SMART substudy finds people on treatment less likely to transmit HIV, and may take fewer risks
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CROI: Smoking increases cancer-associated HPV viral load
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CROI: Circumcision could particularly benefit higher-risk men
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CROI: HIV testing in New York's bath houses is feasible and reaches men missed by traditional prevention
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CROI: New NNRTI, TMC278, demonstrates sustained potency, better CNS and lipid profile than efavirenz, in treatment-naive
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CROI: Early weaning and formula feeding puts HIV-exposed infants in resource limited settings at high risk of severe diarrhoea and death
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CROI: Rate of CD4 decline is a poor guide to the risk of AIDS, say investigators
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CROI: Once daily Kaletra may be less effective when viral load above 100,000 copies/ml
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CROI: Recent OIs or AIDS strongest predictors of development of resistance in South African first-line failures
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CROI: Haiti is the source of HIV subtype B
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CROI: Anti-HBV drug entecavir also active against HIV and promotes antiretroviral resistance
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CROI: Further evidence that short-course PMTCT prophylaxis compromises mother's future treatment
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CROI: Sexual transmission of HCV not limited to HIV-positive gay men
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CROI: Ugandan study confirms low CD4 count, low body weight, TB and anaemia major risk factors for death after starting ART
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CROI: Effects of transmitted drug resistance on viral load are drug class specific
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CROI: Integrase inhibitor raltegravir (MK-0518) doubles HIV suppression in treatment-experienced patients at 16 weeks
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CROI: Maraviroc shows potent effect in highly treatment-experienced
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CROI: Non-AIDS malignancies now more common than AIDS-defining cancers in people with HIV
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CROI: HIV treatment should not be delayed in TB patients with low CD4 counts, South African study shows
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CROI: Cotrimoxazole prophylaxis reduces risk of death by 41% during first six months of ART
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CROI: Microbicide failure poses more questions than answers
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CROI: Kaletra less likely to cause fat loss than efavirenz when paired with NRTIs
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CROI: Women infected with HIV subtype D progress faster despite same viral load
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CROI: MSF reports good responses on PI-based second-line ART regimens even though switch from failing regimens comes late
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CROI: Alendronate effectively treats bone loss in men and women with HIV
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CROI: Growth hormone stimulant TH9507 safe and effective in HIV lipodystrophy
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CROI: Lower CD4 count on HIV treatment predicts higher risk of cancers, liver, kidney, cardiovascular disease
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CROI: Tenofovir microbicide stops rectal infection in monkeys better than PrEP
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CROI: Efavirenz-based ART more effective than nevirapine-based ART as first-line therapy in Southern Africa
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CROI: SMART analysis reveals slightly elevated risk of cardiovascular disease in people who interrupt therapy
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CROI: Urgent action needed to avert `catastrophic` drug-resistant TB epidemic
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New publications from the International HIV/AIDS Alliance

Young children and HIV: Strengthening family and community support

This is the latest booklet in the series of Building Block Africa-wide briefing notes. Young children and HIV provides practical guidance on meeting the developmental needs of young children affected by HIV and the care and treatment needs of young children living with HIV. Focusing on children under eight years of age, it aims to help local organisations and service providers to strengthen family and community support for these children.

‘Young children and HIV’ is structured in two sections:

The first section describes the impact of HIV on the intellectual, emotional, psychological and social development of all young children and what organisations can do to help families and communities to meet children’s developmental needs.

The second section describes the impact of HIV infection on young children and what organisations can do to support families and communities to provide good care and treatment for young children living with HIV.

This booklet is intended for organisations that already have and are using Building Blocks: Africa wide briefing notes. This and the other seven briefing notes in the series are designed to help communities and local organisations to support children made vulnerable by HIV and AIDS. As well as local NGOs and CBOs, the briefing notes may be useful for government and policy makers. 

PDF and hard copies are available at:http://www.aidsalliance.org/sw44797.asp

Building Blocks in Practice – Participatory tools to improve the development of care and support for orphans and vulnerable children

The French adaptation of this manual (Bâtissons l'espoir, en pratique) is now available for the first time in print.

This manual was designed to help communities assess the situations and needs of their children and the available resources, and to identify what action they can take, using the ‘participatory learning in action’ process.

There are seven sets of tools, corresponding to the seven topics in the Building Blocks briefing notes: overview, education, health and nutrition, economic strengthening, psychosocial support, social inclusion, and older people as carers.

PDF and hard copies are available at: http://www.aidsalliance.org/sw24505.asp

This publication is also available in English and Portuguese (the Portuguese adaptation will be available in print later this year).

Let's talk about HIV counselling and testing - Facilitators' guide

Tools to build NGO/CBO capacity to mobilise communities for HIV counselling and testing

This toolkit is designed to help NGOs, CBOs and other civil society organisations increase their knowledge and improve the quality of their work on HIV counselling and testing.

‘Let’s talk about HIV counselling and testing’ has eight sections covering different aspects of  counselling and testing:

  1. What is HIV? What is AIDS?
  2. What is involved in HIV counselling and testing?
  3. Who is providing HIV counselling and testing services in the community?
  4. Who is HIV counselling and testing for?
  5. What are the advantages of and barriers to HIV counselling and testing?
  6. What are the issues around stigma, discrimination and confidentiality?
  7. What are our needs after we test for HIV?
  8. Ideas for an activity in the community

Each section begins by providing essential information comprising key definitions, concepts and messages after which participatory activities are presented for carrying out with NGO/CBO staff.

The resource is intended for use by NGOs and trainers who support such groups and has been designed to be used flexibly, either in capacity building workshops or during technical support visits.

An English PDF and hard copies are available at: http://www.aidsalliance.org/sw37361.asp

An adaptation of this manual is also avail be as a PDF in Spanish.

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.