Other HIV entry targets

In addition to fusion and co-receptor inhibitors, there are additional ways to block HIV entry into cells. One such approach is to target the gp120 protein on the HIV envelope. Researchers are studying small molecules that prevent gp120 from attaching to CD4. In test-tube studies, researchers have also tested agents called glycosylation inhibitors (including castanospermine) that prevent the normal formation of the sugars that make up the gp120 glycoprotein, so they no longer fit the CD4 receptor.

Researchers at the University of Wisconsin have also reported the development of a synthetic peptide-like molecule that, in vitro, has been able to prevent interaction between the HIV protein gp41 and proteins in the host cells.