Resistance

Resistance to maraviroc occurs through the escape of X4-tropic virus that is not suppressed by maraviroc’s action as a CCR5 antagonist.

Overall, more treatment failures occurred in the MOTIVATE study, and occurred more quickly, in persons who developed shifts away from purely R5-tropic virus. At baseline, 751 maraviroc-treated people had purely R5-tropic virus. Of these, 63 treatment failures occurred in people who had developed X4-tropic or dual/mixed virus, compared to 35 failures in people who still displayed only R5-tropic virus. Time to failure with an X4 or dual/mixed virus was approximately 30 days shorter than for failure with R5-tropic virus.

Although it was not surprising that treatment failure would be associated with the emergence of X4- or dual-tropic virus, a less expected finding was that increases in CD4 cell counts were seen even if maraviroc treatment failed virologically.1

Maraviroc has no cross-resistance to drugs from other classes.

References

  1. van der Ryst E et al. Changes in HIV-1 co-receptor tropism for patients participating in the maraviroc MOTIVATE 1 and 2 clinical trials. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, abstract H-715, 2007
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

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We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

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