Studies in animals

Published: 07 April 2009

Animal studies have provided evidence that post-exposure prophylaxis (PEP) can prevent infection with HIV or similar viruses. One showed that antiretroviral therapy prevented simian immunodeficiency virus (SIV) infection in macaques, while a further study has shown that tenofovir (Viread) can prevent infection after intravenous inoculation with SIV, when the drug is given within 24 hours of inoculation and for at least 28 days.1 Tenofovir also prevented infection of macaques with HIV-2 when it was given within 36 hours of exposure.2

References

  1. Tsai CC et al. Effectiveness of post-inoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent SIV infection depends critically on timing of initiation and duration of treatment. J Virol 72: 4265-4273, 1998
  2. Otten RA et al. Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2). J Virol 74: 9771-9775, 2000
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.