Syphilis

Published: 07 April 2009

As with other forms of GUD, the ulcers that form during the early stages of syphilis can facilitate HIV transmission both to and from the infected individual. Studies have also shown that syphilis can increase HIV viral load and lower CD4 cell counts.1,2 High rates of HIV incidence have also been found in gay men with syphilis in North America.3 It has been estimated that syphilis increases the risk of HIV infection two- to five-fold.

References

  1. Buchacz K et al. Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS 18: 2075-2079, 2004
  2. Palacios R et al. Impact of syphilis infection on HIV viral load and CD4 cell counts in HIV-infected patients. J Acqir Immune Defic Syndr 44: 356-359, 2007
  3. Buchacz K et al. HIV incidence among men diagnosed with early syphilis in Atlanta, San Francisco, and Los Angeles, 2004-2005. J Acquir Immune Defic Syndr 47: 234-240, 2008
This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.