Pre-treatment CD4 cell counts and viral load

After 24 months of follow-up, a review of mostly male patients found that higher baseline CD4 cell count was associated with greater trunk fat increase, and higher baseline viral load was associated with greater fat loss in both the trunk and the limbs. 1

CD4 cell count prior to PI treatment has been identified as a predictor of current total fat mass,2 and low nadir (lowest-ever) CD4 cell counts have been associated with worsened lipodystrophy.3 4 5

References

  1. McDermott AY et al. CD4+ cell count, viral load, and highly active antiretroviral therapy use are independent predictors of body composition alterations in HIV-infected adults: a longitudinal study. Clinical Infectious Diseases 41 (11): 1662-1670, 2005
  2. Carr A et al. A HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study. AIDS 15: 1811-1822, 2001
  3. Lichtenstein K et al. Clinical assessment of HIV-associated lipodystrophy in an ambulatory population. AIDS 15(11): 1389-1398, 2001
  4. Lichtenstein KA et al. Incidence of and risk factors for lipoatrophy (abnormal fat loss) in ambulatory HIV-1-infected patients. J Acquir Immune Defic Syndr. 32(1):48-56, 2003
  5. Mauss S et al. Risk factors for the HIV-associated lipodystrophy syndrome in a closed cohort of patients after 3 years of antiretroviral treatment. HIV Medicine 3(1): 49-55, 2002
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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