The pathway to disease

The process by which a micro-organism causes disease is known as pathogenesis. Despite extensive research into AIDS pathogenesis since 1981, large gaps remain in our knowledge of the steps between HIV infection and the development of AIDS. Pathogenesis is the chain of events leading to disease and to disease progression. For example, A affects B, B affects C, and so on, until Y affects Z.

A simple orthodox view of pathogenesis for AIDS is that HIV infection leads to loss of CD4 T-cells and this loss of T-cells results in increased susceptibility to AIDS-related conditions. In reality, there are many more steps in the pathogenesis of AIDS. There are also biological, genetic, social, viral, and environmental factors influencing almost every step. Changes in one factor generally have a ripple effect amongst the others.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.