Methotrexate is an approved anti-cancer drug which inhibits DNA synthesis. It is active against a wide range of tumours and is also used to treat severe psoriasis.

It has severe haematological, pulmonary, gastrointestinal and other toxicities. Common side-effects can include leukopenia (low levels of leukocytes, a type of white blood cell), thrombocytopenia (low levels of platelets), oral ulcers, diarrhoea, nausea and vomiting. It should not be taken by pregnant women.

Taking aspirin can reduce the amount of methotrexate that is excreted by the body, resulting in increased side-effects.

Methotrexate comes in the form of yellow tablets or a liquid for intravenous injection. It is available in a generic (non-brandname) formulation and is also manufactured by Pharmacia & Upjohn under the tradename Maxtrex.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.