Tramadol hydrochloride

Tramadol hydrochloride (Tramake Insts / Zamadol / Zydol / Dromadol SR / Larapam SR / Zamadol 24hr / Zamadol SR / Zydol SR / Zydol XL) is an opioid drug that is used to treat moderate to severe pain. It is available in injectable forms and tablets. It is around 10% as potent as morphine.

In contrast to other opioid drugs, tramadol acts not only through the mu-opioid receptor, but also through affecting other brain chemicals, including gamma-amino butyric acid (GABA), noradrenaline and 5-hydroxytryptamine (serotonin).

Tramadol’s side-effects include nausea, vomiting and sweating, as well as mild drowsiness. Tramadol is unlikely to inhibit breathing or to cause dependence.

Tramadol may interact with protease inhibitors and the non-nucleoside reverse transcriptase inhibitor efavirenz (Sustiva). However, further research is required to establish how important these interactions may be.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.